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Wednesday, May 18, 2022

A non-invasive method of preventing liver cancer offers great promise

Scientists working on cancer treatment have successfully removed many liver tumors with ultrasound, which allows the immune system to clear the remaining cancer cells in rats.

Researchers have developed a sound technology that breaks down liver tumors in mice, destroys cancer cells, and strengthens the immune system. This could lead to improved cancer outcomes in humans, according to a news release.

The researchers used 50 to 75 percent of the liver tumors to break down the rest of the rat’s immune system using unaffected sound technology. The results were amazing. 80% of the mice were cancer-free, with no recurrence or metastatic problems.

“Even if we do not completely target the tumor, we will reduce the risk of recurrence and reduce the risk of metastasis in the future,” said Jean-Shu, a professor of biomedical engineering at the University of Michigan and co-author of the study. In Cancers.

Non-invasive sound technology stimulates the rat’s immune response, which is why the unintended tumor eventually recedes and stops the cancer from spreading.

The treatment is called histostripes.

Histotripsy is a pioneer in the field of research at the University of Michigan in the United States, and is based on a process called cavitation, which creates a vacuum in solid tissue. It is a relatively new method of human liver cancer testing in the United States and Europe today.

700kHz, 260-element histotripsy ultrasound array transducer used in Professor Xu’s laboratory. (Marcin Shesepansky / Multimedia Narrator / Michigan Engineering)

In most cancers, the tumor cannot be completely targeted because it may be too large, too large, or too hard to reach. This latest study aims to eliminate the effective intact tumor by targeting and partially destroying each mass component. In this way, the team at Michigan Medical and Anne Arbor VA Hospital can verify the effectiveness of the presentation to a lesser extent.

“Historripsy is a promising option for safe and effective liver transplantation by overcoming the limitations of existing methods of removal,” says Tejaswi Worlycar, a doctoral student in biomedical engineering at the University of Michigan.

“We hope that the lessons learned from this study will encourage future clinical and clinical histopathology screening for the ultimate goal of clinical adoption of histopathology treatment for liver cancer patients.”

Globally, liver cancer is the third leading cause of cancer death. By 2020, an estimated 830,180 people will die from the disease.

According to the authors, “Symptoms associated with liver cancer may not appear at first, making patients more susceptible to nodal and distant metastases, which estimate a 5-year survival rate of 3-11%. Metastasis shows clinical interest in improving liver cancer.

“In fact, there is metastasis. [more than] Ninety percent of cancer-related deaths and metastatic progress are mainly controlled by complex signaling pathways between the main tumor and the stromal cells, especially the immune system.

Engineers at the University of Michigan (UM) have been able to develop sound waves using conventional ultrasound for a cancer treatment machine. The big plus is that there are no side effects such as radiation and chemotherapy, which are now popular methods of treating cancer.

“Our translator, designed and built on UM, delivers high-amplitude micro-second-length ultrasound pulse – acoustic cavitation – specifically focused on breaking the tumor,” Xu says. “Traditional ultrasound equipment uses low amplitude pulses for imaging.”

The UM Transductor sends a microbe’s second heartbeat and then produces micro bubbles in the target tissues. According to the news release, the bubbles are expanding rapidly and falling. The “violent but very close” explosion of mechanical stress that kills cancer cells breaks the tumor structure.

His Laboratory at the University of Michigan has been working on histopathology cancer treatment since 2001, and # HOPE4LIVER conducted a clinical trial with the support of Michigan Spinoff, a company with histosonics. As of late, the team’s study provided “promising results” in the treatment of histopathology in psychiatry and vaccination.

Source: TRTWorld and Agencies

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