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Thursday, August 11, 2022

A reported case of a patient with gastric lymphoma that affects the bone marrow with the presence of myeloma

The term “MALT” is an acronym for “mucosa-associated lymphoid tissue”.

MALT is diagnosed after upper gastrointestinal endoscopy because of mild dyspeptic symptoms. Photo: Shutterstock.

MALT lymphoma is a type of lymphoma that can affect various organs of the human body, including the stomach (gastric MALT lymphoma).

Meanwhile, extranodal marginal zone lymphoma (ENMZL) is a generally indolent disease, a rare form of malignant non-Hodgkin’s lymphoma, which affects B cells and develops at the expense of cell-associated lymphoid tissue. mucous membranes, although it also occurs, more rarely, in the lymph nodes.

A clinical case accurately recorded in Puerto Rico showed a rare scenario of biclonal gammopathy that developed for nearly 20 years in a patient with MALT lymphoma.

An 82-year-old Hispanic patient with a long history of ENMZL of gastric origin responded to antibiotic treatment with eradication of the bacteria

Helicobacter pylori, but the disease progressed over time with a biclonal gammopathy and marked plasmacytic differentiation with bone marrow involvement.

Biclonal gammopathies are characterized by clonal proliferation of plasma cells, or their B lymphoid progenitors, with the production of two abnormal immunoglobulins (M protein or paraprotein). Paraproteinemias, however, are diseases characterized by an imbalance of immunoglobulin-producing cells that occurs with MALT lymphoma and strongly correlates with bone marrow involvement, and this involvement leads to disease progression.

The description of this patient’s case suggests that her disease evolved gradually from a typical case of gastric MALT lymphoma, eventually with plasmacytic differentiation, which suggests that patients with MALT may not be able to detect potential relapse. should be followed regularly and possible changes should also be detected. Plasma cell neoplasm.

“Because of this, we suggest that patients with ENMZL be routinely assessed for the presence of paraproteins,” the case publication reads.

MALT-type gastric lymphoma is an oncological pathology that should be taken into account when studying a patient with a potential gastric neoplasm, as its clinical presentation is similar to that of most gastric neoplasms and its treatment currently consists in eradicating H. pylori.

MALT is usually diagnosed after upper gastrointestinal endoscopy for mild dyspeptic symptoms. Endoscopic ultrasound is important to determine the presence of lymphoma infiltration and lymph nodes in the gastric wall.

Access the case here.

World Nation News Desk
World Nation News Deskhttps://worldnationnews.com/
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