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Wednesday, December 07, 2022

Anticovid treatments that should no longer be used

Anticovid treatments that should no longer be used

In the world, more than 600 million people have been diagnosed with COVID-19 since the start of the pandemic and more than 6.4 million people have lost the battle to this virus. Effective vaccines have been developed to control this public health problem and Which has been implemented on 64% of the world’s population And some treatments were also included for people at high risk of this infection.

According to the Infobae web portal, since 2020 till date, at least 5,398 clinical trials on various drugs have been registered, where their efficacy and safety are assessed individually or in association with others for COVID-19. went.

Looking at the risks caused by certain drugs, a group of experts World Health Organization (WHO) is monitoring and reviewing the results of these studies and clinical trials, and updating the “Living Guide” which serves as a guide for health officials and healthcare workers. for that reason, WHO specifies which drugs should be indicated and which should be avoided so as not to harm patients or because they do not provide a benefit to treatment COVID-19.

In particular, the Eleventh Edition of the WHO Guide provides some recommendations for systemic corticosteroids, such as dexamethasone, in severe or severe patients; interleukin-6 receptor blockers (such as tocilizumab or sarilumab), in combination with corticosteroids; and baricitinib as an alternative to IL-6 receptor blockers, in combination with corticosteroids.

Too Gives a conditional recommendation for the consumption of the organization casirivimab-imdevimab drug Seronegative status in critically or critically ill patients, when rapid viral genotyping is available and coronavirus infection is confirmed. However, the WHO warned that the effectiveness of this drug is limited when people are exposed to the Omicron version of the coronavirus.

Meanwhile, for Covid-19 patients who are not in critical condition but are at risk of hospitalization, the WHO recommends the use of nirmatrelvir-ritonavir (known by its trademark Paxlovid) in tablet form under a doctor’s supervision. Is. , This medicine blocks a natural substance in the body to stop the spread of coronavirus.

For patients at high risk of hospitalization, conditional recommendations were made to indicate the drugs, when rapid testing is available and infection is confirmed, are mollupiravir, sotrovimab, cisarivimab-imdevimab.

apart from this, It has been clarified that patients with non-severe COVID-19 should not use systemic corticosteroids or recovered plasma. In patients at low risk of hospitalization, nirmatrelvir-ritonavir should not be indicated and in patients with severe and severe COVID-19, convalescent plasma is not recommended.

In turn, the WHO does not recommend Use ruxolitinib and tofacitinib, hydroxychloroquine, and lopinavir-ritonavir. Many experts gave a strong recommendation against the use of ivermectin, except in the context of a clinical trial.

“Some doctors have been reluctant to switch to proven alternatives. Ivermectin and Fluvoxamine, Notably, they are widely prescribed, despite accumulating evidence showing that both treatments at acceptable doses are not effective for COVID-19,” say experts.

Another drug that is not recommended for use in cases of COVID-19 is fluvoxamine, Used to treat depression, and the use of colchicine in non-severe patients is also not recommended.

In this sense, one of the experts participating in the production of the evidence-based recommendations, Ariel Izkovic, a physician and consultant to the Pan American Health Organization (PAHO), told Infobe that “antivirals reduce the progression of serious disease.” But today, if people have received vaccines, including boosters, the risk of developing a serious condition is so low that those who benefit from the drugs are small. You have to choose them very carefully, as these drugs tend to cost more.,

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