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Monday, January 24, 2022

Breakthrough COVID-19 hospitalizations: who gets sick when vaccines don’t work?

As the new omicron variant continues to spread in the United States, vaccinated people who are older or sick are at greatest risk of hospitalization due to breakthrough COVID-19 infection, according to a new analysis by the Kaiser Family Foundation.

But vaccinations still provide some protection because these breakthrough diseases are shorter and milder than those in unvaccinated people, research has shown.

“This tells us that older adults and those with pre-existing high-risk diseases should continue to be cautious about COVID, especially given the new option,” said study author and public health expert Cynthia Cox, vice president of the Kaiser Family Foundation.

“Even though these hospitalizations do occur, the vaccine provides significant protection to people,” she added.

Until now, much is unknown about why some vaccinated people end up in the hospital with COVID-19. With growing evidence of immunosuppression and breakthrough infections in fully vaccinated individuals, experts have tried to answer this question: How well do vaccinations prevent severe illness and hospitalization?

This new study is the first closer look at the characteristics of vaccinated people who are severely ill and their experiences of hospitalization after hospitalization. It is hosted by the Kaiser Family Foundation and Epic Systems, a healthcare software company. It is based on an analysis of electronic health records of 120,000 patients admitted to 250 hospitals in all 50 states between June and September.

The study was conducted before the discovery of a new omicron variant and before the booster dose was available, but the clinical course of these “breakthrough” experiments is likely to be similar, Cox said.

“Older people have weaker immune systems,” Cox said, “and the vaccine is not as effective for them as it might be for younger people.”

Public health experts continue to believe that breakthrough infections are relatively rare and rarely result in hospitalization. Of all hospitalizations for COVID-19, the vast majority (85%) were in people who had not been vaccinated, according to a new study.

But in the future, more cases are expected among those vaccinated. Compared to the delta variant, which is still widespread in the United States, omicron is better able to overcome the immunity caused by the vaccine. In this study, many people were vaccinated more than six months ago and may have experienced decreased immunity.

The analysis found that more than two-thirds (69%) of COVID-19 hospitalizations are in people aged 65 and over. One fifth (21%) are among people aged 50–64 years. Only 10% occurred among young people. In contrast, most people who were not fully vaccinated and hospitalized with COVID-19 were under the age of 64.

Read Also:  What recent science tells us about the fast-spreading omicron

Vaccinated adults hospitalized with the COVID-19 coronavirus – young or old – are more likely to have chronic health problems such as hypertension, diabetes, heart failure, or chronic obstructive pulmonary disease.

But these patients are less likely than unvaccinated people to suffer from the worst effects of COVID-19, such as pneumonia or respiratory failure. They were also less likely to need ventilator support or treatment with the anti-inflammatory drug dexamethasone.

And their hospital stay was shorter. The median hospital stay was 5.6 days for seniors who were fully vaccinated, compared with 6.7 days for people who were not vaccinated or partially vaccinated.

“This suggests that even though these people are hospitalized for COVID, the severity of their illness appears to be lower,” Cox said. “So the vaccine is still helping them.”

This is likely because T cells – a type of white blood cell that plays an important role in the human immune system – can provide reliable protection against the virus in vaccinated people. Despite the breakthrough infection, T cells appear to help prevent serious illness.

Since the beginning of the pandemic, the elderly and the chronically ill have been hardest hit[[[[

“The problem is that most of this (elderly) population suffers from chronic disease,” said Los Altos geriatrics specialist Dr. Mehrdad Ayati. In December, 12 to 15 of his skilled nursing patients were hospitalized for infectious diseases. All were vaccinated and many were revaccinated.

He added that they are more vulnerable to all pathogens, not just the breakthrough SARS CoV-2 infections. “With any infection, COVID or non-COVID, they are more likely to end up in the hospital,” he said.

When older people become infected, “other health problems flare up,” Ayati said. “For example, if they have heart problems, heart failure will start to show. If they have diabetes, it is likely to be uncontrollable. “

In addition, older adults are less able to control the virus. During aging, the immune system changes in two main ways. One of these is a gradual decline in immune function, called immunosagination, which interferes with the recognition and elimination of the pathogen. Another change is an increased risk of inflammation, called inflammation, which results from an overactive but ineffective alert system.

The study highlights the need to take extra precautions for older people and those with chronic illnesses, she said.

World Nation News Deskhttps://www.worldnationnews.com
World Nation News is a digital news portal website. Which provides important and latest breaking news updates to our audience in an effective and efficient ways, like world’s top stories, entertainment, sports, technology and much more news.
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