Sunday, March 3, 2024

Can the human brain regenerate itself?

The human brain, the extraordinary organ where they exist, organizes the complexities of our thoughts, feelings, and bodily functions. however, He is not immune to the effects of time and disease. Understanding the process of degeneration of human brain cells is of utmost importance to unravel the mechanisms behind various neurological disorders.

Now a new study from the Netherlands Institute for Neuroscience shows once again why scientists have been discussing these questions and possible answers for many years. New work published in the journal neuron, shows Why are there conflicting results? about it and proposes a roadmap on how to solve these problems.

Definitely, Brain repair is one of the most important challenges in medicine, Typically, damaged brain cells cannot regenerate and permanent motor and cognitive impairment may result.

among other things, Natural changes occur in the human brain as we age, There is a gradual decline in the function and number of brain cells. Neurons, the building blocks of the brain, may become less efficient at transmitting electrical signals, resulting in cognitive and sensory changes. In addition, the brain experiences a slight decrease in overall volume and weight, which is also reflected in the loss of neurons and their connections.

Finding a solution to this problem may be important, especially in the absence of effective therapeutic strategies in neurodegenerative disorders such as Alzheimer’s disease.

dry grass studies i made a post who showed that new cells can, in fact, be generated during adulthood in the hippocampus of our brains, a structure that plays a key role in learning and memory, and is also severely impaired in hippocampal disease. however, Other investigations contradict these results due to the inability to detect neurons in this region.

The answer may lie in the next generation of technologies. Recent advances in single cell transcriptomic technologies have provided valuable data on different cell types based on brain examinations of deceased donors with various brain diseases.

In this work, the researchers re-analyzed previously published data sets, examining several specific challenges that require special attention.

‘These new technologies, when properly applied, provide a unique opportunity to map hippocampal regeneration in the human brain and identify which cells are targets for therapeutic intervention in ageing, neurodegenerative and neuropsychiatric diseases. The type and state may be most responsive. however, Reproducibility and stability are key. While performing the analysis, we realized that some seemingly small, but otherwise very important details and parameters in the experimental and computational pipeline can have a large impact on the results and thus affect the interpretation of the results. dilara ayildizResearchers under the direction of Evgenia Salta at the Laboratory of Neurogenesis and Neurodegeneration in the Netherlands.

It became clear in their investigation that there are important factors in the investigation such as the interval between the death of the donor and the subsequent procedure, because Tissue quality and the resulting data degrade over time.

“Once we reanalyzed these previous studies using common computational pipelines and criteria, we realized that the apparent controversy in the field can actually be misleading: with our work we propose that there are actually more A lot can happen, which we used to believe.” The expert draws conclusions.

Reference:

“Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: settling the controversy or fueling the debate?” by Giorgia Tosoni, Dilara Ayyildiz, Julien Bryois, Will Macnair, Carlos P. Fitzsimons, Paul J. Lucsen and Evgenia Salta, 3 Apr 2023, Neuron. DOI: 10.1016/j.neuron.2023.03.010

Alessandro Zambusi, Clara Tereza Novoselic, Saskia Hutton, Sofia Kalpzidou, Kristina Koportido, Rico Shivec, Sven Eschenbroich, Lara Silva, Ayse Seda Yazgili, Frauke van Baber, Bettina Schmid, Gabriele Möller, Clara Tritscher, Christian Stieglohr, Claire Delbridge, Svetlana Sirko , Zeynep Irem Gunes, Sabine Leibscher, Jürgen Schlegel, Hananeh Elie, Fabian Theis, Silke Meiners, Michael Keibler, Dorothy Dormann, Jovica Ninkovic. TDP-43 condensates and lipid droplets modulate microglia reactivity and regeneration after traumatic brain injury. Nature Neuroscience, 2022; 25 (12): 1608 doi: 10.1038/s41593-022-01199-y

Satoshi Tanikawa, Yuki Ebisu, Tomas Sedlasik, Shingo Semba, Takayuki Nonoyama, Takayuki Kurokawa, Akira Hirota, Taiga Takahashi, Kazushi Yamaguchi, Masamichi Imazo, Hinako Kato, Takuya Nishimura, Zen-ichi Tanei, Masumi Tsuda, Tomomi Nemoto, Xian Ping Gong , Shinya Tanaka. Engineering of an electrically charged hydrogel implanted in a traumatic brain injury model for stepwise neuronal tissue reconstruction. Scientific Reports, 2023; 13 (1) doi: 10.1038/s41598-023-28870-z

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