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Tuesday, December 06, 2022

Efficient nanoparticles designed in the treatment of immunotherapy

Efficient nanoparticles designed in the treatment of immunotherapy

researchers of cancer research center (CIC), Mixed Center Superior Council of Scientific Inquiry (CSIC) and University of Salamanca (USAL) has developed a nanoparticle-based drug that has demonstrated its efficacy in the treatment and follow-up of cancer immunotherapy. study, published in Journal of NanobiotechnologyCharacterized and rated in vitro I in vivo Application of nanoparticles that specifically identify and attack only tumor cells.

“We have evaluated some nanoparticles that offer both an antitumor drug derived from cisplatin and a molecule that allows monitoring and detection of nanoparticles in biological systems,” he explains. Manuel Fuentes, CIC researcher. Fuentes’ team analyzed what happens from when the nanoparticles are administered to the tumor area. The characterization and evaluation of its applications opens the door for the design of new antitumor drugs with application in immunotherapy.

one of the functions of immune system To identify and eliminate cancer cells in the body. If all the cancer cells disappear, the cancer also disappears with them. However, sometimes cancer cells develop mechanisms so that the immune system cannot detect them and, therefore, they are not eliminated from the body by an immune response.

a very promising area of ​​research cancer, There is immunotherapy, including hematological tumors, where research is being done on how to prevent tumor cells from hiding from the immune system. By knowing these feedback mechanisms, new drugs can be developed that improve the function of detecting and eliminating cancer cells.

“In order to achieve this objective of identification and elimination, when cancer cells In the body going unnoticed, the immune system must be manipulated so that it can do this function properly, and that is the framework in which we are working”, the researcher says.

nanomedicine This is a feature of biomedicine that may provide solutions and the design of new, more efficient drugs. Nanomedicine works by combining nanoparticles that allow the immune response to be manipulated, acting specifically on cancer cells and not on healthy cells. Thus, it allows the development of personalized and precision medicine, avoiding many of the side effects of chemotherapy by acting only on the cells that must be eliminated. Another advantage of nanoparticles is that they detect cancer cells and deliver the drug to the tumor; It even facilitates tumor cell entry to improve its efficiency and reduce toxicity in the area of ​​tissue damage.

under investigation nanoparticles Its interaction with its biological environment must be analyzed, based on this relationship with the nanoparticle’s biomolecules, which will determine the drug’s efficiency, as it affects the absorption, distribution and mechanism of entry into the cell, with itself in interaction with the immune system. This relationship may change across species, therefore, it may determine the development of preclinical and clinical trials.

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