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Monday, December 05, 2022

First maternal vaccine against bronchiolitis revolutionized pediatrics

First maternal vaccine against bronchiolitis revolutionized pediatrics

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The first maternal vaccine against bronchiolitis achieved more than 80% protection in clinical trials, which means a A “revolution” in pediatrics to combat this acute respiratory infectionone of the following Leading cause of death in children under one year of ageExperts explained this on Wednesday.

US laboratory Pfizer reported that the completion of Phase III clinical trials showed that the vaccine achieved 81.8% protection against infection caused by respiratory syncytial virus (RSV) in the first 90 days of life. and kept one 69.4% efficacy by six months,

,This vaccine predicts a revolution in the health system. The results are tremendously conclusive, last time it was thought to reach 40% protection and it was not reached, and now it is much higher. It will change the course of pediatrics, because it will free hospitals from so many severe cases,” Fernando Pollack, scientific director of the Infant Foundation, told Telum.

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About bronchiolitis

Bronchiolitis is an acute respiratory infection that occurs more often in the autumn-winter months, and mainly affects children under 1 year of age. It can be caused by various viruses; The most common is respiratory syncytial virus (RSV).

“70% of babies admitted to hospital in winter are due to bronchiolitis, overflowing hospitals, creating enormous strain on the medical service,” said Pollack, “50% die at home in developing countries, they die a silent death.” Huh”.

Data from the Ministry of Health

according to the last National Epidemiological Bulletin of the Ministry of National Health, 173,723 cases of bronchiolitis were reported in 2022With a cumulative incidence rate of 11,861.8 cases/100,000 inhabitants.

Every year in Argentina this disease is caused by RSV. It causes about 20,000 hospitalizations and about 600 preventable deaths among children under one year of age.

“There would be a paradigm shift with a vaccine, as vaccination would prevent 80% of hospitalizations in severe cases,” explained Pollack.

Bronchiolitis Vaccine Targets

This type of vaccine is given pregnantLike flu or whooping cough today, so that the child is prepared to deal with these diseases, thanks to the antibodies provided by the mother.

“It is a vaccine designed to be given to the mother, who has had contact with the virus several times during her life, then it passes antibodies to the baby through the placenta. With its antibodies the baby is protected for up to 6 months .“, explained Teelam Romina Liebster, pediatrician, researcher and specialist in vaccines.

“The most vulnerable moment is the first year, and especially the first 6 months, so what is demanded is that when he is born he is already protected,” he said.

clinical trials

in clinical trials studies 7,400 pregnant women under the age of 49 from 18 countries participated since June 2020, Starting in the late second trimester of pregnancy, half the mothers randomly received a single dose of the vaccine and the other half a placebo version.

In Argentina, 942 women participated. In the study at the Military Hospital of Buenos Aires, Osacque, and in health centers in the provinces of Salta and Tucumán.

Mothers are nursed up to six months after delivery and children up to one year of life. A subgroup of the boys will be followed for two years.

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photo file.

Upon receiving positive results in the Maternal Immunization for Safety and Efficacy (MATIS) study, Pfizer anticipated submitting the data for publication in a scientific journal. Then, it is expected that the United States Food and Drug Administration (FDA, for its abbreviation in English), the European Medicines Agency (EMA) and Argentina’s mandate, among other regulatory bodies, will approve the procedure in the coming months. .

If approved, this would be the world’s first maternal vaccine against bronchiolitis virus in infants.

“This will fundamentally change public health. It prevents 80% of severe disease in the first three months of life, the impact is huge,” Liebster said.

The expert concluded, “This vaccine has the potential to not only save lives but also have an impact on the reality of millions of families.”

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