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Wednesday, October 5, 2022

Immune system versus virus: why were Omicron’s experts concerned from the start?

Illustration Of Antibodies That Respond To Infection With Sars-Cov-2.
in great shape , Illustration of antibodies that respond to infection with SARS-CoV-2.

Getty Images/Kateryna Kon/Science Photo Library

From the very first description of Omicron, researchers were concerned about the type of SARS-CoV-2 virus. Given the list of mutations it carries, scientists can identify a number that would likely make the variant more contagious. Other mutations were even more worrisome, as they would potentially interfere with the immune system’s ability to recognize the virus, making it a risk for people who had been vaccinated or suffered previous infections.

Buried in the subtext of these concerns was an obvious implication: scientists could simply look at the sequence of amino acids in a coronavirus’s spike protein and understand how well the immune system would respond.

This knowledge is based on years of study of how the immune system works, along with a lot of specific information about its interaction with SARS-CoV-2. What follows is a description of these interactions, along with viral evolution and their implications for current and future forms.

TS and BS

To understand the function of the immune system, it is easiest to break down its responses into categories. To begin with, there is an innate immune response, which recognizes the general characteristics of pathogens rather than the specific properties of individual bacteria or viruses. Vaccination or prior exposure to the virus does not ameliorate the innate response, so it is not really relevant to the discussion of variants.

What we are interested in is the adaptive immune response, which recognizes distinctive features in pathogens and generates a memory that elicits a rapid and robust response when the same pathogen is seen again. It is this adaptive immune response that we are stimulating with vaccines.

Adaptive response can also be broken down into categories. In terms of relevant immune responses, we care most about those mediated by antibody-producing B cells. The other major part of adaptive immunity, the T cell, uses an entirely different mechanism to recognize pathogens. We know very little about the response of T cells to SARS-CoV-2, but we will come back to this later. For now, we’ll focus on the antibodies.

Antibodies are large (in molecular terms) combinations of four proteins. Most of the proteins are the same in all antibodies, which allows immune cells to interact with them. But each of the four proteins has a variable region that differs in each B cell produced. Many variable regions are useless, and others are recognized by the body’s own proteins and are eliminated. But incidentally, some antibodies have variable regions that recognize a segment of a protein made by a pathogen.

An Antibody Molecule.  Variable Regions In The Red And Blue Portions Of The Molecule Combine To Form A Binding Region That Pathogens Can Recognize.
in great shape , an antibody molecule. Variable regions in the red and blue portions of the molecule combine to form a binding region that pathogens can recognize.

The part of the protein of the pathogen that the antibody recognizes is called an epitope. Epitopes differ from protein to protein, but they share some characteristics. For antibodies to collide in the first place they must be on the exterior of the protein, rather than buried in its interior. And they often have amino acids that are polar or charged, as these have strong interactions with antibodies.

You can’t just look at the amino acid in an antibody and tell what it’s going to bind to. But if you have a sufficient amount of a specific antibody, it is possible to do what is called “epitope mapping,” which involves finding out where on the protein the antibody is binding. In some cases, it may include a precise list of amino acids that the antibody recognizes.

In general, having antibodies to a pathogen in the bloodstream makes it easier for the pathogen to be seen and disposed of by specialized immune cells—for this task, it doesn’t really matter where the antibody sticks. But there are also specific interactions that can inactivate the virus in some cases, as we’ll see below.

World Nation News Desk
World Nation News Deskhttps://worldnationnews.com/
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