The Jewish link. – New Israeli technology to deliver precise dosing could significantly reduce the side effects of cancer drugs and revive many treatments now considered unsafe, scientists said Friday. The Times of Israel,
The team suggests that the invention could also allow doctors to increase the dosage of some existing drugs. Techno-Israel Institute of Technology In recent peer-reviewed research.
Precision medicine is seen as a promising way to treat cancer, but a major challenge is the technology needed to deliver drugs without taking cancer cells to other parts of the body.
particles are called nanocarriers, a key component of most coronavirus vaccines, work well. but every nanocarrier It is compatible with a limited range of drugs, and only a few dozen are available, meaning that most drugs cannot be administered as precision medicine.
a biomedical engineering team from technion say they invented a new nanocarrierTested it in laboratory conditions and in rats, and concluded that it has the potential to make nanodosing possible for many drugs.
“New nanocarrier This actually allowed us to successfully treat mice with a drug that cannot normally be used because of its acute side effects,” said Professor Yossi Shame, head of the laboratory that conducted the research.
His team gave mice trametinib, a drug that can only be used today for melanoma patients and in small doses because of its toxicity. The rats got what is considered a safe dose. The mice that received it as a normal drug did not improve, while the mice that received it nanocarriers Ended up with targeted small tumors.
Shame commented: “It nanocarrier This could allow us to use potentially life-saving drugs that are not feasible because the side effects of the required dosage are too intense. It’s exciting. Laboratory tests indicate that it will work with many drugs and with a wide range of cancers.
“In addition, it could make existing drugs more effective. As we need to limit the dosage of some drugs today because of side effects, the precise delivery that addresses those concerns, the larger and therefore more effective doses.” may allow,” he said.
Shame’s lab invented the particle using an unusual process. He built a robot and programmed it to try out different combinations of materials after adding them through various chemical reactions.
“By taking a major step forward in robotic chemistry, we have opened up new opportunities for medicine,” explained Shame.
“Currently, most drugs need to be administered as regular oral or injectable drugs, which means they are eliminated throughout the body. If this happens, 99% of the drug gets into healthy cells. and less than 1% go into the tumor.
“This new material allows us to deliver drugs with great precision in solid tumors. Side effects from a drug that ends up elsewhere in the body can be significantly reduced.”
“And if you can reduce the side effects, you can also increase the dosage, because the dosage is often prescribed to limit the side effects, you can increase the performance of a drug,” he said.
Shamay said that the preliminary test of ability nanocarrier To maintain its payload, that is, the drug being tested, was made possible safely and stably by using a light-based method. If the drug is stable, it emits almost no light when illuminated.
He carried out this process of laboratory tests on 30 drugs. they were all stable nanocarrierwhich, according to Sham, suggests that nanocarrier It will work with many drugs. Their goal is to conduct further testing and obtain regulatory approval.
Shame said: “If all goes well, in five years we will have patients who will receive our material. This could have a very positive impact on cancer treatment.”
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