- It is possible to detect signs of Parkinson’s 20 to 30 years before symptoms appear
- This was demonstrated by researchers from The Florey and Austin Health, in Australia.
- A known biomarker called F-AV-133 can be used to diagnose Parkinson’s disease
Researchers from The Florey and Austin Health, in Australia, have shown that this is possible to find the clues manifestation of the disease Parkinson’s between 20 and 30 years before symptoms appear. Their work, published in the journal ‘Neurology’, opens the door to detection programs and preventive treatments before irreversible damage occurs.
Kevin Barnham, professor at The Florey, says Parkinson’s and neurodegenerative disease Disappointingly, it is often considered a disease of old age, when in fact it begins in middle age and may go unnoticed for decades.
The disease Parkinson’s is very difficult to diagnose
“The disease of Parkinson es very difficult diagnosis until symptoms appear, where up to 85% of the neurons in the brain that control motor coordination are destroyed, he explained. At this point, many treatments are likely to be ineffective. Our long-term goal is to find a way to detect the disease earlier and treat people before damage is done,” he added.
In their study, lead researcher Professor Barnham and colleagues describe how a known biomarker called F-AV-133 can be used in positron emission tomography (PET) scans of disease diagnosis Parkinson’s disease and accurate tracking of neurodegeneration.
In the Melbourne study, Florey Professor Chris Rowe and his team at Austin Health scanned 26 patients with Parkinson’s disease, a control group of 12 people and 11 people with commotion on BEHAVIOR on DREAM by rapid eye movement (RBD), which is a strong indicator of the disease.
Every person is subject to both PET scanners two years apart. According to the results, there were no significant changes in clinical symptoms for any of the participants based on currently available assessments for Parkinson’s disease.
In contrast, a PET scan shows a “loss of neuronal essential” In three key brain regions of individuals with the disease, suggesting that F-AV-133 is a more sensitive way to monitor neurodegeneration than what is currently available.
According to their calculations and mathematical models: a total of approximately 33 years of slow neuron loss in Parkinson’s disease. This loss occurs for about 10.5 years before the disease is detected on a PET scan, and once the PET scan detects the disease, it takes another six and a half years before motor symptoms appear.
Behind the APPEARANCE of symptom physical, others pass three years to prove the HE diagnosis clinical. This corresponds to neuronal loss occurring at about 22.5 years before clinical symptoms are sufficient for diagnosis.
Professor Barnham points out that this finds open roads to develop screening protocols to diagnose and treat Parkinson’s disease up to 10 years earlier than is currently possible. It also helps identify patients for clinical trials.
People with RBD scream or thrash, sometimes violently, in their sleep and act out vivid, unpleasant dreams. the CAUSE is the lack of muscle atony (sleep paralysis) and 90% of these people with RBD develop Parkinsonian disease.
The HALF of persons with Parkinson’s suffer from RBD, making it an important early warning sign of Parkinson’s disease. Therefore, researchers recommend people with RBD to consult a sleep specialist and/or a neurologist.
