The Ministry of Health has notified the first two deaths in Spain Hepatitis of unknown origin in childrenAfter not being able to overcome the liver transplant to which he was subjected.
According to the health report published this Thursday, a 6-year-old boy from Murcia was transferred to a Madrid hospital, started having symptoms on July 2, was transplanted on July 29 and died 24 hours after the transplant.
The second deceased is a 15-month-old girl living in Andalusia Those who were admitted at the end of June in a critical condition (encephalopathy and severe coagulopathy) with symptoms of acute gastroenteritis with positive culture for adenovirus. The case required an urgent liver transplant and he also died within the next 24 hours.
The Community of Madrid, for its part, has so far reported the existence of Fifteen cases of acute hepatitis of unknown origin in children, In the framework of the investigation launched after the first case was reported in the United Kingdom.
Also, out of the 46 cases detected in Spain so far, it has had to be Another transplant of a 3-year-old girl living in Aragon.
These are minors of middle age 0 and 16 years With more than 60 per cent girls, according to data as of August 3 from the National Epidemiological Surveillance Network, led by the health ministry.
Five cases are less than 1 year of age, and 3 of them, with onset of symptoms in late June, are two neonates aged 3 and 5 days (admitted in the ICU) and a 48-day-old baby with enterovirus Adenovirus was detected in one of them and SARS-CoV-2 in the other.
cases have been detected 10 autonomous communities, Without an epidemiological relationship between them and symptoms began between January 2 and July 2, most of which were detected between March 7 and May 1.
Cases are distributed by autonomous communities as follows: Andalusia (3), Aragon (1), Balearic Islands (4), Canary Islands (1), Castilla y León (2), Castilla-La Mancha (3), Catalonia (9), Galicia (5), Madrid (15) and Murcia (3).
The average age of the cases under investigation was 5.3 years and the mean age was 4 years. On the basis of gender, 29 cases were girls (64.4%) and 16 were boys (35.6%), with a higher proportion of girls, especially in the age group of 0 to 5 years.
Among the cases in which information on symptoms is available, the most frequent were malaise (26 cases; 65%), vomiting (26 cases; 59%), fever (23 cases; 58%) and abdominal pain (21 cases; 50%). ). Jaundice was reported in 20 cases (50%), diarrhea in 12 cases (29%), respiratory symptoms in 10 cases (25%), and rash in 9 cases (23%).
At the National Center for Microbiology (CNM) of the Carlos III Institutes of Health (ISCIII), Microbiological and metagenomic investigations. 7 positive cases have been detected for herpes virus and 10 out of 21 (47.6%) analyzed have been positive for adenovirus, so it remains the main suspect behind these cases.
In any case, Health assures that “so far, the number of hepatitis cases of unknown cause in children and transplants seen in this alert are expected in accordance with estimates made with data from previous years.”
In fact, Health states that a comparative analysis among autonomous communities found “an increase in cases of severe hepatitis of unknown origin in children aged 0 to 16 in the period January to May 2022 compared to the same period of the previous five years.” Is not observed. years, nor in the separation of codes and ages».