The use of proton pump inhibitors (PPIs) such as omeprazole has been the subject of controversy in recent years because of its possible association with colon cancer. Although these drugs are widely used to reduce gastric acid secretion and treat certain stomach ailments, studies have suggested that their long-term use may major health risksincluding a possible increased risk of gastric cancer.
In 2017, a study published in british journal of medicine (BMJ) and conducted by University College London and the University of Hong Kong, revealed an association between PPI use and an increased risk of gastric cancer. Researchers analyzed 63,000 people who had overcome the infection Helicobacter pylori and found that people who were treated with PPIs were twice as likely to develop cancer than people who received other reflux treatments. In addition, the study indicated that those taking daily omeprazole had Four times higher risk of developing colon cancer compared to those who took it weekly.
evidence pending evidence
However, it is important to note that the scientific evidence on this association is not yet conclusive. A meta-analysis published in the journal diet pharmacology and medical law suggests that there is not enough evidence to definitively confirm this link. Still, the authors of the study consider the need reduce needed PPI prescriptions due to actual overconsumption of these drugs,
In Spain, colon cancer is one of the least frequent cancers, but its incidence is still high. According to the Spanish Society of Medical Oncology (SEOM), it was estimated that in 2022 there would be approximately 6,913 cases of gastric cancer, mainly in men. Although death rates from this type of cancer have decreased in recent decades, 4,917 people still died from the disease in 2020.
colic prevention
Other than this Helicobacter pyloriOther risk factors for gastric cancer include chronic inflammation of the stomach, gastroesophageal reflux disease, gastric polyps, smoking, obesity, and a diet low in vegetables and high in processed meats. In cases where these conditions or infections are present, doctors may recommend the use of drugs such as omeprazole to treat and prevent stomach disorders.
In short, although there are studies that suggest a possible association between long-term use of proton pump inhibitors, such as omeprazole, and an increased risk of gastric cancer, the scientific evidence is still inconclusive. It is necessary to follow medical recommendations and avoid self-medication.
