Friday, June 9, 2023

Senolytica, the revolutionary promise of cellular cleansing

What if you could leave an old heart for a new one? and your brain? What other parts of the body are aging? This is what one of the main protagonists in the search for longevity promises: the senolytics.

light“Canus” means a process, “lytic” anti-aging, senolytic is properly anti-aging.

Aging cells are bad influences for strong cells; they do this, so that one rotten evil can rot the whole bowl. That’s why senolytics promise the following: It works by eliminating hooligans that cause healthy cells to pass to the side.

Since 2008, work has been done with intensity in the Church the change is aging using the “senolytic hypothesis”. The basic mission: to use senolytic agents (some synthetic, some natural) to old and damaged cells (called senescent or senile cells) to slow down the aging process.

For example, scientists at the University of California, San Francisco (United States) continuously infused blood from young mice into old mice, and found that the old mice functioned like young ones. One effect was that it increased the number of stem cells and growth factors in the old mice. The theory is that senescent cells remain in the body, increasing in number with age, contributing to inflammation, secreting highly destructive substances that cause the neighboring healthy cells to age.

youthful promise

A study of moles in I stick to mayo The human future of senolytics looks promising. A photograph from the study shows two old moles, both the same age, from the same litter, and with the greatest differences between them. He who had been born naturally retreated and looked forward to the old man; the other, who had received senolytic treatment, had a cheerful disposition. The difference was apparent from the outside, and not counting the changes that were taking place inside.

Other researchers reported that the senolytic treatment changed blood so much that older mice gave blood from young mice, going from 109 weeks to 30 weeks. At present, promising experiments with senolytics are carried out in all parts of the animal’s body, from restoring vision to fixing discs in the spine.

But the senolytic consequences of the heart and brain are most interesting. The cells that pump the heart need precise timing to move blood throughout the body with maximum efficiency. As we age and our cells age, that synchronization can be thrown out of whack, leading to dangerous health effects like heart failure or fluid in the lungs. Senolytic offers the promise of a better heart by restoring youthful function to the cells that power the heart.

In studies by Mayo Clinic researchers, two drugs that have been tested for other uses appear to have a senolytic effect on the heart. Combined, they extract and remove old cells, allowing neighboring cells to recover their normal function and improve the heart’s ability to pump blood.

Research challenges

One of the great challenges to the study of aging is as follows; old age is indeed a cluster of diseasesprocesses, conditions and system errors that cause loss of years and quality of life.

Finally, of course, death is the end of the game. But to look at any treatment, researchers need a specific goal, either a title of success or failure. This is why treatments such as senolytics are used in conditions such as knee arthritis or back pain, or stem cell heart failure patients; results can be measured in tangible and specific results.

Researchers cannot measure a person’s time of death because there is no way to know what the time of death would have been otherwise, with or without treatment. But to study death in the population, you have to wait and see if this drug, or treatment, or lifestyle change, such as intermittent fasting, also affects the age at which people die, which affects more years than most scientists.

So now there will be some extrapolation: for example, if senolytics can reverse arthritis, can they be applied to aging in general? Could a senolytic drug that eliminates knee inflammation and pain be injected into the brain to prevent memory decline?

This is a promising treatment that, if it works, could be available in the United States after FDA approval sometime in 2026. Add to that senolytic treatments for joints in the back, knees, heart and lungs, or in the brain and eyes. , we were able to renew another 12 years before 2003.

World Nation News Desk
World Nation News Desk
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