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Thursday, February 2, 2023

Study: The liver may produce harmful proteins that cause Alzheimer’s disease

September 14 (WNN)—— A mouse study published on Tuesday by PLOS Biology showed that a type of lipoprotein produced in the liver causes brain cells to break down, leading to the development of Alzheimer’s disease and other forms of dementia.

Researchers say this protein called amyloid has previously been linked to Alzheimer’s disease, which is the most common form of dementia.

It is known that the deposition of a protein, amyloid β, can disrupt brain cell function in patients with Alzheimer’s disease.

However, at least until now, it is not clear whether this protein produced by multiple organs in the body is produced in the brain or elsewhere.

The researchers said these new findings suggest that the liver may play an important role in the onset or progression of Alzheimer’s disease.

“In order to prevent and treat Alzheimer’s disease, we need to understand the real cause of this disease,” study co-author John Mamo told WNN in an email.

Ma Mo, Professor of Health Sciences at Curtin University, said: “This study shows that high levels of potentially toxic lipoproteins in the blood can damage tiny cerebral blood vessels called capillaries and leak into the brain, causing inflammation and brain cell death. “Perth, Australia.

The Alzheimer’s Association estimates that approximately 6 million people in the United States have been diagnosed with Alzheimer’s disease, making it the most common form of dementia.

Using magnetic resonance imaging or MRI to identify amyloid beta deposits in the brains of patients with Alzheimer’s disease can help make the diagnosis of the disease easier and possible early treatment.

However, there is no cure for Alzheimer’s disease, and available drug therapies can only slow its progression in some cases.

Mamo said that understanding how these amyloid deposits are formed in the brain can help researchers identify drugs that can prevent them.

In addition, dietary adjustments, such as reducing the intake of high-fat foods, may “potentially” slow down the production of these proteins in the liver, thereby lowering blood levels and preventing them from accumulating in the brain, he said.

In this study, Mamo and his colleagues used mice that can produce human amyloid beta in the liver.

In mice, the researchers found that this protein is carried in the blood by triglyceride-rich lipoproteins (also produced by the liver) to the brain, just like in humans.

It is also known that lipoproteins rich in triglycerides can spread triglycerides (a type of cholesterol) from the digestive system to the blood, and in the blood to the whole body, which may damage organs such as the brain and heart.

Researchers say that mice with high levels of amyloid and triglyceride-rich lipoproteins experienced neurodegeneration – or loss of brain cell structure and function – and brain atrophy, or weight loss.

This brain atrophy is accompanied by inflammation of nerves, arteries, and veins in the brain, and damage to brain capillaries, which are common in Alzheimer’s disease patients.

The affected mice performed poorly on learning tests that depend on the function of the hippocampus, which is an essential part of the brain to form new memories.

The researchers said that these findings need to be confirmed in human studies before they can be used to formulate prevention and treatment strategies for Alzheimer’s disease.

However, according to Mamo, Australian researchers have begun the first human study of a drug designed to slow the development of amyloid lipoprotein in the liver.

“The disorder of brain capillaries is the first sign of Alzheimer’s disease, many years before cognitive decline,” Mamo said.

“Determining the cause of capillary damage and theoretically preventing it from happening may have a huge impact on the onset and progression of Alzheimer’s disease,” he said.

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World Nation News Desk
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