Researchers from the Department of Pharmacobiology of the Center for Research and Advanced Studies (Cinvestav) undertook the task of analyzing the relationship between obesity and cardiac hypertrophy in childhood, both risk factors for heart failure, that is, heart failure. enough to pump blood to the rest of the body.
David Iulián Arias Chávez, Guadalupe Bravo and Norma Leticia Gómez VÃquez participated in the investigation.
The Ministry of Health (SSA) has linked childhood and excessive consumption of refined sugars with obesity and the development of an enlarged heart, commonly known as cardiac hypertrophy.
Obese children between the ages of 3 and 12 have been reported to develop cardiac hypertrophy; that is, they did not have to become adults, or present with arterial hypertension, in order to present these complications.
“The importance of research in analyzing the appearance of cardiac hypertrophy in young mice that were administered drinks with an excessive content of refined sugar and/or fructose, looking for similar feeding conditions to children in Mexico, who from the first months. Drinks that receive an abundance of sugars of age, explained Arias Chávez.
What is cardiac hypertrophy?
Hypertrophy of the heart increases the size of the heart due to pressure overload which usually occurs in arterial hypertension. Likewise, “there is an elongation of the cavities in response to an increase in blood volume caused, normally, by an excess of body fat,” reads a Cinvestav bulletin.
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“We noticed that the excessive consumption of sugary drinks induced by obesity from an early age significantly increases oxidative stress and the oxidation of CaMKII in the heart, which occurs in cardiac hypertrophy; this allowed us to understand the fundamentals of cardiac pathophysiology to rebuild in states of obesity and oxidative stress, so that it can stop its development” , the researcher explained.
The results of the investigation
The research protocol consisted of serving drinks with sucrose, fructose and together with two said to an animal model of three-week-old newly weaned rats. After 5 months of intake, there was a significant excess of adipose tissue compared to the group that received drinking water without carbohydrates.
“We verified that sugary diets, in addition to cardiac hypertrophy, oxidative stress and CamKII hyperactivation, also generated an increase in blood pressure, triglycerides, cholesterol, type 2 diabetes and possibly metabolic syndrome, higher in the composition of the diet”, Arias Chavez. he said.
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The study concluded that excessive sugar intake from an early age can cause malnutrition, metabolic damage, increase excess adipose tissue and oxidative stress, favoring the development of cardiac hypertrophy and, over time, heart failure.
“This vigil would be a call to families to prevent children from consuming too many products with a high content of these sugars and/or sugar drinks, in order to prevent the development of irreversible heart diseases and the possibility of increasing them in adulthood,” David Iulián Arias Chavez maintained.
According to the National Institute of Public Health, Mexico ranks first in the consumption of sugary drinks; The diet of the population, from childhood, includes sugary (refined sugars) and fructose (high fructose corn syrups) fruits, which are refined carbohydrates into juices, nectars and soft drinks.
