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Tuesday, October 4, 2022

US study finds Ivermectin has no meaningful effect on treating COVID

Ivermectin, an anti-parasitic drug, which was popularized as a way to treat COVID-19 at home despite warnings from the Food and Drug Administration, may not reduce symptoms or require hospitalization, according to the clinical OR was not shown to have a meaningful effect in reducing the rate of death. Test results published on Sunday.

The study, led by scientists at Duke University and Vanderbilt University, involved 1,591 participants who received 400 mcg/kg of ivermectin, which is often used to treat livestock, or a placebo. Forty-seven percent of participants said they had received at least two doses of a COVID vaccine.

This clinical trial has not yet been peer-reviewed.

The main measure of effectiveness of ivermectin used in the study was based on sustained recovery time, defined as three consecutive days without any COVID symptoms. In a document reviewing study results, the major secondary outcome included a composite of hospitalization or death by day 28, wrote Susanna Negi, MD, MHS, of Duke Clinical Research Institute, one of the researchers involved in the study.

The document states that taking ivermectin for three days resulted in “less than a day of reduction in symptoms and no reduction in the incidence of hospitalization or death with COVID-19 in the United States.” Hui.”

This clinical trial was part of the Accelerated COVID-19 Therapeutic Intervention and Vaccines (ACTIV)-6 study group, which examines whether certain FDA-approved drugs may be effective in treating patients over the age of 30. , including early mild-to-moderate COVID.

“ACTIV-6 adds to the growing evidence that ivermectin does not have a clinically relevant treatment effect at this dose and duration,” wrote Nagy. “While there appeared to be a beneficial treatment effect with ivermectin compared with placebo in people with severe symptoms at baseline, this subgroup was small, thus these findings should be considered exploratory.”

The findings of this study are in line with the findings of another large clinical trial in Brazil, which was published in May by the New England Journal of Medicine.

Those researchers concluded, “Treatment with ivermectin did not result in the progression of COVID-19 or a lower incidence of medical admission to hospital due to prolonged emergency department observation among outpatients with an early diagnosis of COVID-19.” “

Despite the lack of evidence that the drug has a substantial effect against COVID, ivermectin has major boosters, including by podcaster Joe Rogan.

Rogan shared a story on Twitter in February, falsely claiming that the drug was effective against the Omicron variant in Phase III clinical trials. After it was wrong, Rogan deleted the tweet.

Last year, Rogan said that he took the drug after testing positive for COVID as a treatment in September 2021.

A month ago, the FDA tweeted warning people against self-treating with ivermectin, which is commonly used on animals.

“You’re not a horse. You’re not a cow. Seriously, you all. Stop this,” the agency tweeted in August 2021.

The FDA also published a detailed post on its website explaining why Americans should stay away from the drug.

In Arkansas, prisoners filed a lawsuit against a doctor who inadvertently gave them the drug as a COVID treatment. A Northwest county in the state, however, later in February issued a resolution praising the doctor.

World Nation News Desk
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