Tuesday, December 06, 2022

Vitamin D deficiency associated with worse overall survival in melanoma patients

Vitamin D deficiency associated with worse overall survival in melanoma patients

Vitamin D levels affect overall survival of melanoma patients, shows a new study presented on 31st Congress of the European Academy of Dermatology and Venereology (EADV).

The researchers found that people with vitamin D deficiency (less than 10 ng/ml) were twice as likely to survive (hazard ratio 2.3) worse than those with low vitamin D levels after a melanoma diagnosis. Vitamin D equivalent/10 ng/ml.

Retrospective study analyzed a cohort of 264 patients with invasive melanoma Clinical Hospital of Barcelona, To investigate whether the vitamin plays a protective role in melanoma survival.

The study examined differences in overall survival and melanoma-specific survival between groups using statistical analysis techniques such as Kaplan–Meier curves and . cox regression To control for confounding variables.

The results remained significant even after adjusting the model for age at diagnosis, gender, Breslow index (depth of melanoma from the skin’s surface to the deepest point), and season. Risk of 2.4 in multivariate analysis.

In contrast to previous studies, our study showed that baseline characteristics at the time of melanoma diagnosis (age, gender, patient phototype, location, histological subtype, Breslow index, ulceration and tumor mitotic index) were not associated with differences in vitamin D levels . In addition, vitamin D deficiency was not shown. Vitamin D will affect survival Melanoma specific.

principal investigator, Dr. Ines Gracia-Dardefrom Son Espaces University Hospital, explains that “although previous research has identified that normal levels of vitamin D play a protective role in melanoma survival, this study aimed to better understand this relationship.”

“These results suggest that vitamin D has a significant effect in people with melanoma, particularly indicating that patients with vitamin D deficiency.” vitamin D Their overall survival is short,” he added.

Melanoma is a type of skin cancer that develops when melanocytes (the cells that give skin its color) grow out of control. In 2020, melanoma was estimated to account for 4% of all new cancer diagnoses and 1.3% Of all cancer deaths in EU-27. Of these, 50,972 were diagnosed in women and 55,597 in men. In 2020, EU-27 had 7,031 deaths among women and 9,457 among men.

Dr. Gracia-Darder states that “although the mechanism underlying the relationship between the vitamins” Still more research is needed for D and melanoma overall survival, It is hoped that this study will encourage further research into whether vitamin D supplementation may have the potential to improve the prognosis of vitamin D-deficient melanoma patients and increase their overall survival.”

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