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Tuesday, January 31, 2023

Why was the introduction of bivalent vaccines against Covid postponed?

“Should I get the vaccine now or wait till it comes bivalent vaccine, This, at this time, is the most recurring question in the face of a further rise in infections COVID-19Even without definite information on its scope, and the rebound in demand, vaccination is more focused in the Metropolitan Area of ​​Buenos Aires (AMBA).

pfizer why modern, Two producers of those supplements adapted to deal with the Omicron version., they had already confirmed through the medium that they are available if the country requests them. But a sharp drop in vaccinations during the year with the arrival of more doses generated an oversupply of stocks, which today would be about 12.3 million doses for children and adults, a figure that makes disentanglement in application records difficult. National and provincial health authorities. forced to do it all ministry of health of the nation To postpone the distribution of the bivalent vaccines “to sometime next year,” according to what The Medium has unofficially learned.

At the current rate, that could be one million applications this month, twice as much as last month when vaccination attendance rose again, replacements will be linked to more than expiration dates. 94% of the doses served are from Moderna and 5%, from Pfizer, according to monitoring of the vaccination campaign by ln data, Other brands have 1%.

Different astrazeneca, laboratories Richmond o Pfizer, which extended the expiration date of its products to between two and twelve months, according to the brand Modern Dose is marketed with a longer initial expiration of nine months, which was not reported by the US lab, which it attributes Can be modified by the formulation. Not even at the request of the officials of the Ministry of Health of the nation, according to the report of the portfolio directed by them Carla Vizzotti After a meeting last month. On the table, there was a figure under discussion: some six million doses, between pediatric and adult, that could expire without being implemented and in the short term (next January and March).

The last official update of acquired vaccines is last August with the arrival of 537,900 Pfizer Sera for adults and pediatrics. 12.87 crore doses of the six brands procured since December 2020 have arrived in the country. With declared donations totaling 5,083,000 units to other countries, the national vaccination campaign for COVID-19 ultimately retained just over 123.6 million doses, of which 7.1 million are held by provinces that have not been implemented – due to the number May vary due to delays or lack of ability to load data for the federal Nomivac vaccination registry – and 5.2 million from the nation.

With these numbers, one does not risk the arrival date of the bivalent vaccines. Health Ministry did not respond to the consultation Country,

In pfizer He confined himself to expressing that “the current procurement agreement enables them to obtain customized versions of the vaccines.” Rafo Laboratory, Moderna’s local representative replied that they would start distributing them “when the government requests it”. As mentioned, the amendment to the agreement for the purchase of 20 million doses [no incluye los 3,5 millones de unidades de esa firma donados por Estados Unidos] It envisages completing the distribution of the remaining amount equivalent to approximately US$133 million with pediatric and bivalent doses.

A review of how such a high excess stock was achieved reveals that applications fell from 10.6 million to 5.4 million between January and February, when the health ministry responded that progress had been made with the first reinforcements or the primary framework. was being started or completed. In March and April, with school and pediatric immunization enabled, the country saw no more than 2.9 and 2 million applications, respectively, rising to more than 4.1 million with the announcement of the fourth dose (second booster) in May and October. fell again to reach its lowest value in a month with 275,309 in the U.S., when infections rose again without officially reported figures.

later that month, after a meeting of federal health council (COFESA) It was reported that by November the third reinforcement or fifth dose had been enabled. Last month, applications nearly doubled from October, with a 206% jump (319,354 applications) in the week between November 27 and December 3. Since then 73% of people vaccinated have been over the age of 50.

“There are some countries that are giving a fifth dose, such as the United States, Canada and England, where bivalent vaccines are used, including the ancestral strain (Wuhan) and the BA sublineage. 4 and BA. 5 omicrons, which evolved and caused further evolution. In preliminary studies, in addition to tests in animal models, it was already observed that the bivalent dose increases the relative effectiveness of vaccination in the short and long term,” he explained. Edward Lopezhead of medical department Children’s Hospital Ricardo Gutierrez,

“In Argentina, we are vaccinating with a fifth dose produced with the S protein of the original version of the Covid-19 virus. It is logical that the population wonders whether it is effective against the subvariant of Omicron – said the infectionologist -. It will be necessary to complete the third and fourth doses first, as there are still many people who have not received them. Absent them, today, there is not enough vaccination being done and even if it is a mild form of the disease, the virus continues to spread and must be controlled.

In this sense, and given the new increase in infections, whose epidemiological magnitude is unknown due to limitations in tests and low reporting of outpatient diagnoses, López expressed: “We are vaccinating with a good vaccine, but Given that variant dominant and sub-lineage in circulation, the impact of protection is less than that of bivalent. Now, in the current epidemiological scenario, the best recommendation is that primarily over 50 and immunosuppressed people who have received six or eight received the last dose months before they were vaccinated. In those groups, at that time, the level of antibodies against the original strain [del SARS-CoV-2] has come down and to flatten this curve it is necessary to strengthen it”.

In collaboration with Gabriela Bourret, Natalia Lauzau and Melanie Prokopiek

Conocé Trust Project
World Nation News Desk
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